Physostigmine For Alzheimer's Disease
Physostigmine is a cholinesterase inhibitor and preserves acetylcholine levels in brain cells.
Physostigmine, taken orally, is broken down rapidly in the blood, so that its
effects are not very long-lasting . Because physostigmine has such a short
life in blood, it has not been found to be effective in alzheimer patients when
given orally [153-154]. However, physostigmine is most effective orally when
given for long periods of time,up to 6 weeks .
Physostigmine effectively enhances cognitive ability when it is administered
intravenously. Studies using intravenous physostigmine show good to excellent
results in more than half of all patients [156-157]. When physostigmine is
administered in transdermal patch,its effectiveness is comparable to the
Physostigmine has been found to
increase blood flow to the brains of alzheimer patients . As you may
recall, blood flow is reduced in the brains of alzheimer patients.