Indomethacin For Alzheimer's Disease
Indomethacin is a non-steroidal, anti-inflammatory drug used to treat pain. Indomethacin use has
been shown to reduce the risk of alzheimer's disease. Indomethacin has been used
clinically for alzheimer patients. One study gave patients 100 to 150 milligrams
of indomethacin daily for six months. Patients receiving indomethacin increased
their cognitive abilities 1.3 percent on a battery of tests; whereas, those
patients not receiving indomethacin declined 8.4 percent .
How does the drug work? Studies have shown the
indomethacin does not alter the toxic effects of amyloid beta protein [102-103].
However,indomethacin does reduce the activation of brain microglia .
Microglia are the immune regulators in the brain, much like white blood cells
are immune regulators in the bloodstream. In alzheimer patients, microglia
become hyper-activated, and may aggravate brain injury by secreting harmful
chemicals,such as nitric oxide.
Indomethacin should be
used cautiously in alzheimer patients. One study reports that indomethacin can
precipitate psychotic like episodes -including agitation, confusion,and
aggression- in sensitive alzheimer patients .